Inside the Evolution Engine Powering Medical Breakthroughs

Schematic of the T7-ORACLE system. The genome is maintained by the non-mutagenic host replisome (gray), while an orthogonal T7 replisome (red) maintains only a dedicated plasmid (OR) at 100,000-fold elevated mutation rate.

Scientists have just created what could be the ultimate game-changer for medical breakthroughs: an “evolution engine” that can reprogram proteins thousands of times faster than nature intended. This revolutionary platform, called T7-ORACLE, developed by researchers at Scripps Research, is like giving evolution a fast-forward button that could accelerate the development of life-saving therapies for cancer, […]